Ranking October 2025
Protein design

The RankmyAI Protein Design Ranking presents the top tools from our Overall ranking focusing on protein design.

 

Protein design tools help scientists and researchers create or improve proteins for specific uses. These tools are used in fields like medicine, biology, and biotechnology to develop things like enzymes, antibodies, and treatments. They support work such as building new proteins from scratch, improving how proteins work, or making them more stable and effective for research and medical use.

 

The green up and red down arrows indicate how many positions a tool has increased or decreased compared to the previous month's ranking. A grey dash means the tool's position has remained unchanged.

Top 16 out of
17
1
Generate Biomedicines Generate:Biomedicines pioneers generative biology to create breakthrough medicines, expanding technical possibilities with The Generate Platform. This approach transforms therapeutic development by generating novel medicines across multiple modalities on demand.
paid
United States
2
EvolutionaryScale ESM3 is an advanced AI model family for protein sequence modeling, enabling scientists to explore biological data and create novel proteins, enhancing scientific understanding and innovation.
unknown
United States
+1
3
Cradle Cradle facilitates protein engineering by predicting and designing improved protein sequences through machine learning. It enhances existing biotechnology processes by offering performance predictions and accelerating the development timeline.
paid
Netherlands
-1
4
Basecamp Research Basecamp Research leverages proprietary AI and biological data to enable genome and protein design, enhancing biotechnology across pharma sectors via innovative models and integrative techniques.
unknown
United Kingdom
5
Arzeda Arzeda leverages AI and physics-based design to engineer designer proteins and enzymes for improved sustainability and functionality in various industries.
unknown
United States
6
A-Alpha Bio A-Alpha Bio utilizes synthetic biology and machine learning to generate high-resolution protein interaction data, enabling rapid therapeutic discovery. It offers advanced platforms for protein interaction measurement and prediction, accelerating drug discovery and optimization.
unknown
United States
7
Ordaos miniPRO by Ordaōs utilizes generative AI to design innovative mini-proteins for drug discovery, optimizing for binding specificity, solubility, and stability, targeted toward effective therapeutics development.
unknown
United States
8
JURA Bio JURA Bio, Inc. introduces variational synthesis, a generative AI approach to protein sequence design, reducing design costs massively. The platform generates high-quality, cost-effective biologic sequences through innovative model architecture.
unknown
United States
9
Shuimu BioSciences Shuimu BioSciences specializes in cryo-EM technology to accelerate drug discovery through accurate biomolecular structure determination, with expertise in integrating structural biology, protein science, and advanced imaging.
unknown
China
+1
10
Diffuse Bio Diffuse Bio develops generative AI tools, including DSGmini and DiffuseSandbox, to design novel protein sequences and binders quickly on consumer hardware, enabling faster, more accurate protein therapeutic development.
unknown
United States

Not Available

11
Salt AI Salt AI accelerates life sciences advancements by optimizing AI models for drug discovery, protein structure prediction, and biomolecular modeling, enhancing speed and efficiency.
unknown
United States
-2
12
Diagen AI DaGen leverages generative AI to innovate protein and peptide design, transforming drug discovery and development processes by significantly reducing time and cost.
unknown
Canada
-1
13
AminoAnalytica Amina is an AI-native protein design platform that acts as a lab copilot for protein engineers. It unifies leading computational tools like RFdiffusion, ProteinMPNN, AlphaFold, and OpenMM in a browser-based environment with on-demand enterprise GPUs. Users can research, design, fold, dock, predict, and analyze results without coding, accelerating the creation of novel protein drugs and enzymes. Plans range from free academic access to enterprise with custom hosting, API, and advanced security.
unknown
United States

Not Available

14
Ligo Biosciences Ligo Bio is an Oxford-founded biotech startup using generative deep learning to design new enzymes for industrial applications. The company targets challenges that natural evolution hasn’t solved, creating enzymes to manufacture pharmaceuticals, degrade food toxins, and produce fine chemicals, backed by wet lab validation and high-throughput screening. Based in San Francisco, they are actively hiring AI and wet lab scientists.
unknown
United States

Not Available

15
Xyme XYME AI leverages generative AI and experimental data to design enzymes, aiming to revolutionize synthetic chemistry and protein design for life-changing therapies and agrobio solutions.
unknown
United Kingdom
-3
16
Neurosnap Neurosnap offers code-free bioinformatics tools for protein folding, molecular docking, and drug discovery, utilizing advanced AI models to streamline complex biological computations for researchers.
unknown
United States
-3
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Disclaimer

The RankmyAI Protein Design Ranking is based on our Overall ranking, which measures how popular tools are using three types of data: website traffic, user reviews, and funding amounts. These are combined into one score (for more details, see our Methodology page).

Some tools in this list may also be used for purposes other than protein design. This ranking does not judge how good or reliable these tools are. It is only a popularity list and should not be seen as a recommendation or review.

You may use or share this ranking freely, as long as RankmyAI is mentioned as the source (see our Copyright page).

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